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Literature summary for 2.1.1.9 extracted from

  • Weisiger, R.A.; Jakoby, W.B.
    Thiol S-methyltransferase from rat liver (1979), Arch. Biochem. Biophys., 196, 631-637.
    View publication on PubMed

General Stability

General Stability Organism
freezing destroys activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus
0.00054
-
4-Chlorothiophenol
-
Rattus norvegicus
0.0011
-
phenyl sulfide
-
Rattus norvegicus
0.0028
-
4-Nitrothiophenol
-
Rattus norvegicus
0.012
-
Diethylthiocarbamoyl sulfide
-
Rattus norvegicus
0.043
-
2-Thioacetanilide
-
Rattus norvegicus
0.11
-
2-Benzimidazole thiol
-
Rattus norvegicus
0.19
-
thioglycolic acid
-
Rattus norvegicus
0.21
-
L-cysteine methyl ester
-
Rattus norvegicus
0.4
-
N-acetyl-L-cysteine
-
Rattus norvegicus
1
-
6-Propyl-2-thiouracil
-
Rattus norvegicus
1.2
-
2-mercaptopropionic acid
-
Rattus norvegicus
1.4
-
1-methylimidazol-2-thiol
-
Rattus norvegicus
1.6
-
2,3-Dimercaptopropanol
-
Rattus norvegicus
4.7
-
3-mercaptopropionic acid methyl ester
-
Rattus norvegicus
8.1
-
2-mercaptoethanol
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27500
-
1 * 27500, SDS-PAGE Rattus norvegicus
28000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.01
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methylimidazole-2-thiol + S-adenosyl-L-methionine
-
Rattus norvegicus 1-methyl-2-(methylthio)-1H-imidazole + S-adenosyl-L-homocysteine
-
?
2,3-dimercaptopropanol + S-adenosyl-L-methionine
-
Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
?
2-benzimidazole thiol + S-adenosyl-L-methionine
-
Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
?
2-mercaptobenzothiazole + S-adenosyl-L-methionine
-
Rattus norvegicus S-methyl-2-mercaptobenzothiazole + S-adenosyl-L-homocysteine
-
?
2-mercaptoethanol + S-adenosyl-L-methionine
-
Rattus norvegicus S-methyl-2-mercaptoethanol + S-adenosyl-L-homocysteine
-
?
2-mercaptopropionic acid + S-adenosyl-L-methionine
-
Rattus norvegicus S-methyl-2-mercaptopropionic acid + S-adenosyl-L-homocysteine
-
?
2-thioacetanilide + S-adenosyl-L-methionine
-
Rattus norvegicus S-methyl-2-thioacetanilide + S-adenosyl-L-homocysteine
-
?
3-mercaptopropionic acid methyl ester + S-adenosyl-L-methionine
-
Rattus norvegicus S-methyl-3-mercaptopropionic acid methyl ester + S-adenosyl-L-homocysteine
-
?
4-chlorothiophenol + S-adenosyl-L-methionine
-
Rattus norvegicus 4-chloro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
?
4-nitrothiophenol + S-adenosyl-L-methionine
-
Rattus norvegicus 4-nitro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
?
6-propyl-2-thiouracil + S-adenosyl-L-methionine
-
Rattus norvegicus 6-propyl-S-methyl-2-thiouracil + S-adenosyl-L-homocysteine
-
?
6-thiopurine + S-adenosyl-L-methionine
-
Rattus norvegicus S-methyl-6-thiopurine + S-adenosyl-L-homocysteine
-
?
benzylmercaptan + S-adenosyl-L-methionine
-
Rattus norvegicus benzylmethylsulfide + S-adenosyl-L-homocysteine
-
?
diethylthiocarbamoyl sulfide + S-adenosyl-L-methionine
-
Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
?
L-cysteine methyl ester + S-adenosyl-L-methionine
-
Rattus norvegicus S-methyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine
-
?
mercaptoacetic acid + S-adenosyl-L-methionine
-
Rattus norvegicus S-methylmercaptoacetic acid + S-adenosyl-L-homocysteine
-
?
N-acetyl-L-cysteine + S-adenosyl-L-methionine
-
Rattus norvegicus N-acetyl-S-methyl-L-cysteine + S-adenosyl-L-homocysteine
-
?
phenyl sulfide + S-adenosyl-L-methionine
-
Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
?
thiophenol + S-adenosyl-L-methionine
-
Rattus norvegicus S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
?

Subunits

Subunits Comment Organism
monomer 1 * 27500, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.6 8.6 about 50% of maximum activity at pH 6.6 and pH 8.6 Rattus norvegicus