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Literature summary for 2.1.1.80 extracted from

  • Park, J.S.; Cho, J.Y.; Kim, S.S.; Bae, H.J.; Han, J.W.; Lee, H.W.; Hong, S.Y.
    Immunoglobulin can be functionally regulated by protein carboxylmethylation in Fc region (2006), Arch. Pharm. Res., 29, 384-393.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein L-glutamate Sus scrofa anti-bovine serum albumin antibody can be carboxylmethylated via spleen PCMT to a level similar to gamma-globulinglobulin. This carboxylmethylation increased the hydrophobicity of the anti-bovine serum albumin antibody up to 11.4%, and enhances the antigen-binding activity of this antibody up to 24.6%. Protein carboxylmethylation may reversibly regulate the antibody-mediated immunological events via the Fc region S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
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?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
spleen
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Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein L-glutamate anti-bovine serum albumin antibody can be carboxylmethylated via spleen PCMT to a level similar to gamma-globulinglobulin. This carboxylmethylation increased the hydrophobicity of the anti-bovine serum albumin antibody up to 11.4%, and enhances the antigen-binding activity of this antibody up to 24.6%. Protein carboxylmethylation may reversibly regulate the antibody-mediated immunological events via the Fc region Sus scrofa S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
?
S-adenosyl-L-methionine + protein L-glutamate anti-bovine serum albumin antibody can be carboxylmethylated via spleen PCMT to a level similar to gamma-globulinglobulin. This carboxylmethylation increases the hydrophobicity of the anti-bovine serum albumin antibody up to 11.4%, and enhances the antigen-binding activity of this antibody up to 24.6% Sus scrofa S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
?

Synonyms

Synonyms Comment Organism
PCMT
-
Sus scrofa
protein carboxyl O-methyltransferase
-
Sus scrofa