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Literature summary for 2.1.1.8 extracted from
- Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice (2007), Eur. J. Pharmacol., 558, 179-184.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | elevation of endogenous histamine by amodiaquine may play a protective role through the regulation of TNF-alpha production in endotoxin-induced hepatic injury mice | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | subcutaneous injection of amodiaquine in mice with propionibacterium acnes-primed and lipopolysaccharide (LPS)-induced hepatitis significantly increases the histamine levels in the liver in comparison to saline treated mice. Pretreatment with amodiaquine also improves the survival rate of the hepatitis mice, and this improvement is partially associated with the decrease in serum levels of aspartate aminotransferase and alanine aminotransferase. Amodiaquine partially suppresses increases of tumor necrosis factor (TNF)-alpha in the serum and TNF-alpha mRNA expression in the liver | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amodiaquine | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| histamine N-methyltransferase | - |
Mus musculus |
| HNMT | - |
Mus musculus |
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