Literature summary for 2.1.1.8 extracted from

Reuter, M.; Jeste, N.; Klein, T.; Hennig, J.; Goldman, D.; Enoch, M.; Oroszi, G.
Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians (2007), Drug Alcohol Depend., 87, 69-75.

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Application

Application	Comment	Organism
medicine	in German Caucasians the association of the HNMT Thr105Ile polymorphism with alcoholism is not replicated, but a congruent association is found between the Ile105 allele and family history of alcoholism supporting the protective role of the Ile105 allele against alcoholism	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
T105I	Thr105Ile polymorphism is analyzed whether it is associated with alcoholism in German Caucasians. No significant difference is found in the frequency of the Ile105 allele between alcoholics and controls. Likewise, genotype distributions does not differ significantly. Frequency of the Ile105 allele is significantly lower in male alcoholics with a family history of alcoholism compared to that in male alcoholics without a family history of alcoholism	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
histamine N-methyltransferase	-	Homo sapiens
HNMT	-	Homo sapiens

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Release 2023.1 (January 2023)