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Literature summary for 2.1.1.8 extracted from

  • Grassmann, S.; Apelt, J.; Sippl, W.; Ligneau, X.; Pertz, H.H.; Zhao, Y.H.; Arrang, J.M.; Ganellin, C.R.; Schwartz, J.C.; Schunack, W.; Stark, H.
    Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities (2003), Bioorg. Med. Chem., 11, 2163-2174.
    View publication on PubMed
Search for more literature for 2.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
8-(3-(1H-imidazol-4-yl)propoxy)-5-nitroquinoline 50% inhibition at 0.0117 mM, simultaneously a highly potent H3 receptor ligand Rattus norvegicus
N-(2-(1H-imidazol-4-yl)ethyl)-1,2,3,4-tetrahydroacridin-9-amine 50% inhibition at 0.000086 mM, simultaneously a highly potent H3 receptor ligand Rattus norvegicus
N-(2-(1H-imidazol-4-yl)ethyl)-N-methylquinolin-4-amine 50% inhibition at 0.000079 mM, simultaneously a highly potent H3 receptor ligand Rattus norvegicus
N-(2-(1H-imidazol-4-yl)ethyl)quinolin-4-amine 50% inhibition at 0.000055 mM, simultaneously a highly potent H3 receptor ligand Rattus norvegicus
N-(3-(1H-imidazol-4-yl)propyl)-1,2,3,4-tetrahydroacridin-9-amine 50% inhibition at 0.000035 mM, simultaneously a highly potent H3 receptor ligand Rattus norvegicus
N-(3-(1H-imidazol-4-yl)propyl)-2-methylquinolin-4-amine 50% inhibition at 0.000054 mM, simultaneously a highly potent H3 receptor ligand Rattus norvegicus
N-(3-(1H-imidazol-4-yl)propyl)-N-methylquinolin-4-amine 50% inhibition at 0.000035 mM, simultaneously a highly potent H3 receptor ligand Rattus norvegicus
N-(3-(1H-imidazol-4-yl)propyl)quinolin-4-amine 50% inhibition at 0.000024 mM, simultaneously a highly potent H3 receptor ligand Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
HMT
-
 Rattus norvegicus