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Literature summary for 2.1.1.8 extracted from

  • Axelrod, J.
    Histamine N-methyltransferase (pig liver) (1971), Methods Enzymol., 17, 766-769.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
2-Bromolysergic acid diethylamide
-
Cavia porcellus
chlorpromazine
-
Cavia porcellus
chlorpromazine
-
Sus scrofa
Methylhistamine
-
Cavia porcellus
Methylhistamine
-
Sus scrofa
p-chloromercuribenzoate
-
Cavia porcellus
serotonin
-
Cavia porcellus
serotonin
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.035
-
histamine
-
Cavia porcellus
0.38
-
S-adenosyl-L-methionine
-
Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Cavia porcellus
-
liver
-
Sus scrofa
-
spleen
-
Cavia porcellus
-
spleen
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
10.4
-
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histamine highly specific for histamine Cavia porcellus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
?
S-adenosyl-L-methionine + histamine highly specific for histamine Sus scrofa S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Cavia porcellus
37
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.4
-
Cavia porcellus
7.2 7.4
-
Sus scrofa