Literature summary for 2.1.1.76 extracted from

De Luca, V.; Ibrahim, R.K.
Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4-O-methyltransferases (1985), Arch. Biochem. Biophys., 238, 606-618.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3,6,7,3'-Tetramethylquercetagetin	noncompetitive inhibitor	Chrysosplenium americanum
3-methylquercetin	noncompetitive inhibitor with respect to both S-adenosyl-L-methionine and quercetin	Chrysosplenium americanum
S-adenosyl-L-homocysteine	competitive inhibitor with respect to S-adenosyl-L-methionine	Chrysosplenium americanum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone	Chrysosplenium americanum	-	S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone	-	?

Organism

Organism	UniProt	Comment	Textmining
Chrysosplenium americanum	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partially	Chrysosplenium americanum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone	-	Chrysosplenium americanum	S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone	-	?

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Release 2023.1 (January 2023)