Literature summary for 2.1.1.74 extracted from

  • Yamagami, R.; Tomikawa, C.; Shigi, N.; Kazayama, A.; Asai, S.; Takuma, H.; Hirata, A.; Fourmy, D.; Asahara, H.; Watanabe, K.; Yoshizawa, S.; Hori, H.
    Folate-/FAD-dependent tRNA methyltransferase from Thermus thermophilus regulates other modifications in tRNA at low temperatures (2016), Genes Cells, 21, 740-754 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Thermus thermophilus Q5SID2
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + uracil54 in tRNA + FADH2
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Thermus thermophilus tetrahydrofolate + 5-methyluracil54 in tRNA + FAD
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?

Synonyms

Synonyms Comment Organism
TRMFO
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Thermus thermophilus

General Information

General Information Comment Organism
physiological function a gene disruption strain does show any growth retardation at 70°C, but shows a slow-growth phenotype at 50°C with an increase in 2'-O-methylguanosine at position 18 and decrease in N1-methyladenosine at position 58 in the tRNA mixture from the mutant strain at 50°C. The protein synthesis activity of the mutant strain is inferior to that of the wild-type strain at 50°C Thermus thermophilus