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Literature summary for 2.1.1.72 extracted from

  • Wang, Y.; Sheng, Y.; Liu, Y.; Zhang, W.; Cheng, T.; Duan, L.; Pan, B.; Qiao, Y.; Liu, Y.; Gao, S.
    A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N6-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription (2019), Nucleic Acids Res., 47, 11771-11789 .
    View publication on PubMed
Search for more literature for 2.1.1.72

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Tetrahymena thermophila 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine Tetrahymena thermophila
-
 S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
S-adenosyl-L-methionine + DNA adenine Tetrahymena thermophila SB210
-
 S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Organism

Organism UniProt Comment Textmining
Tetrahymena thermophila
-
-
-
Tetrahymena thermophila SB210
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine
-
 Tetrahymena thermophila S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
S-adenosyl-L-methionine + DNA adenine
-
 Tetrahymena thermophila SB210 S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Synonyms

Synonyms Comment Organism
adenine methyltransferase 1
-
 Tetrahymena thermophila
AMT1
-
 Tetrahymena thermophila
DANN 6mA MTase
-
 Tetrahymena thermophila
DNA 6mA methyltransferase
-
 Tetrahymena thermophila

General Information

General Information Comment Organism
malfunction enzyme loss-of-function leads to severe defects in growth and development Tetrahymena thermophila
physiological function the enzyme is required for the bulk of 6-methyladenine and all symmetric methylation at the ApT dinucleotides Tetrahymena thermophila