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Literature summary for 2.1.1.72 extracted from

  • Woodcock, C.; Yu, D.; Hajian, T.; Li, J.; Huang, Y.; Dai, N.; Correa, I.J.; Wu, T.; Vedadi, M.; Zhang, X.; Cheng, X.
    Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro (2019), Cell Discov., 5, 63 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.72

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
MOLM-13 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme complex shows strong activity on single-stranded oligo 6 T (containing GGACT), much reduced activities on 4 T (containing GGAGT) and 4B (AGACT), and no activity on oligos having two substitutions within the recognition, e.g. 6B (AGAGT) or 5 T and 5B (GGATC). Furthermore, the enzyme complex has no activity on an oligo-containing G and C only and no activity on A-containing oligos without matching consensus sequence. The enzyme complex acts on single-stranded DNA (6 T) faster than that on the corresponding single-stranded RNA and is inactive on double-stranded DNA or RNA/DNA hybrid Homo sapiens ?
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S-adenosyl-L-methionine + DNA adenine the enzyme complex is active on single-stranded and unpaired DNA in vitro and methylates GGACT in single-strand DNA and double-strand DNA-containing mismatches Homo sapiens S-adenosyl-L-homocysteine + DNA 6-methyladenine
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 ?

Synonyms

Synonyms Comment Organism
DNA adenine-N6 MTase
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 Homo sapiens
MettL3-MettL14 complex
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 Homo sapiens
sequence-specific DNA adenine methyltransferase
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 Homo sapiens