Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA adenine | Brucella abortus | the DNA target sequence is GANTC | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Caulobacter vibrioides | the DNA target sequence is GANTC, CcrM is more active on hemimethylated than unmethylated DNA | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Escherichia coli | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Klebsiella pneumoniae | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Aeromonas hydrophila | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Salmonella enterica | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Vibrio cholerae serotype O1 | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Yersinia enterocolitica | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Aggregatibacter actinomycetemcomitans | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Campylobacter jejuni | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | Pasteurella multocida | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aeromonas hydrophila | - |
- |
- |
Aggregatibacter actinomycetemcomitans | - |
- |
- |
Brucella abortus | - |
- |
- |
Campylobacter jejuni | - |
- |
- |
Caulobacter vibrioides | - |
- |
- |
Escherichia coli | - |
- |
- |
Klebsiella pneumoniae | - |
- |
- |
Pasteurella multocida | - |
- |
- |
Salmonella enterica | - |
serovar typhimurium | - |
Vibrio cholerae serotype O1 | - |
- |
- |
Yersinia enterocolitica | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GANTC | Brucella abortus | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GANTC, CcrM is more active on hemimethylated than unmethylated DNA | Caulobacter vibrioides | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | Escherichia coli | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | Klebsiella pneumoniae | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | Aeromonas hydrophila | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | Salmonella enterica | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | Vibrio cholerae serotype O1 | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | Yersinia enterocolitica | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | Aggregatibacter actinomycetemcomitans | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | Campylobacter jejuni | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
S-adenosyl-L-methionine + DNA adenine | the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not | Pasteurella multocida | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CcrM | - |
Caulobacter vibrioides |
CcrM methylase | - |
Brucella abortus |
Dam methylase | - |
Escherichia coli |
Dam methylase | - |
Klebsiella pneumoniae |
Dam methylase | - |
Aeromonas hydrophila |
Dam methylase | - |
Salmonella enterica |
Dam methylase | - |
Vibrio cholerae serotype O1 |
Dam methylase | - |
Yersinia enterocolitica |
Dam methylase | - |
Aggregatibacter actinomycetemcomitans |
Dam methylase | - |
Campylobacter jejuni |
Dam methylase | - |
Pasteurella multocida |
DNA adenine methyltransferase | - |
Escherichia coli |
DNA adenine methyltransferase | - |
Brucella abortus |
DNA adenine methyltransferase | - |
Klebsiella pneumoniae |
DNA adenine methyltransferase | - |
Aeromonas hydrophila |
DNA adenine methyltransferase | - |
Salmonella enterica |
DNA adenine methyltransferase | - |
Caulobacter vibrioides |
DNA adenine methyltransferase | - |
Vibrio cholerae serotype O1 |
DNA adenine methyltransferase | - |
Yersinia enterocolitica |
DNA adenine methyltransferase | - |
Aggregatibacter actinomycetemcomitans |
DNA adenine methyltransferase | - |
Campylobacter jejuni |
DNA adenine methyltransferase | - |
Pasteurella multocida |
General Information | Comment | Organism |
---|---|---|
malfunction | a relevant defect of Yersinia enterocolitica Dam overproducers is enhanced invasion capacity, probably associated with transcriptional alterations in invasin genes inv and ail, and with changes in the composition of lipopolysaccharide O-antigen | Yersinia enterocolitica |
malfunction | knockout of a putative DNA methyltransferase gene in Campylobacter jejuni causes reduced motility, aberrant flagellar appearance, and hyperadherence to epithelial cells, accompanied by reduced invasion | Campylobacter jejuni |
malfunction | lack of Dam methylation causes partial attenuation upon intranasal or intraperitoneal inoculation of mice | Klebsiella pneumoniae |
malfunction | mutants lacking Dam methylase are not viable, Dam overproduction does not impair bacterial growth | Vibrio cholerae serotype O1 |
physiological function | CcrM regulates the genes dnaA, ctrA, and ccrM at transcriptional level | Caulobacter vibrioides |
physiological function | Dam methylation may control the expression of virulence genes | Pasteurella multocida |
physiological function | DNA adenine methylation is involved in Aeromonas hydrophila pathogenesis | Brucella abortus |
physiological function | DNA adenine methylation is involved in Aeromonas hydrophila pathogenesis | Aeromonas hydrophila |
physiological function | the formation of 6-methyladenine reduces the thermodynamic stability of DNA and changes DNA curvature, as a consequence, the methylation state of specific adenosine moieties can affect DNA-protein interactions. Dam methylation regulates virulence genes at the posttranscriptional level | Salmonella enterica |
physiological function | the formation of 6-methyladenine reduces the thermodynamic stability of DNA and changes DNA curvature, as a consequence, the methylation state of specific adenosine moieties can affect DNA-protein interactions. Dam methylation regulates virulence genes at the posttranscriptional level. Dam methylation plays a role in enterohemorrhagic Escherichia coli by controlling the production of the virulence factor Shiga toxin 2 | Escherichia coli |