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Literature summary for 2.1.1.72 extracted from

  • Humbert, O.; Salama, N.R.
    The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components (2008), Nucleic Acids Res., 36, 6893-6906.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.72

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli ER2925(DE3) cells Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine Helicobacter pylori M.HpyAXII targets GTAC sites S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
S-adenosyl-L-methionine + DNA adenine Helicobacter pylori NSH57 M.HpyAXII targets GTAC sites S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Helicobacter pylori NSH57
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine M.HpyAXII targets GTAC sites Helicobacter pylori S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
S-adenosyl-L-methionine + DNA adenine M.HpyAXII targets GTAC sites Helicobacter pylori NSH57 S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Synonyms

Synonyms Comment Organism
gamma-adenine MTase
-
 Helicobacter pylori
HpyAXII consists of a restriction endonuclease and a DNA methyltransferase Helicobacter pylori
M.HpyAXII
-
 Helicobacter pylori

General Information

General Information Comment Organism
malfunction deletion of the methyltransferase M.HpyAXII is lethal when associated with an active endonuclease, M.HpyAXII MTase activity is not required for establishing infection in mice Helicobacter pylori