Literature summary for 2.1.1.67 extracted from

Feng, Q.; Vannaprasaht, S.; Peng, Y.; Angsuthum, S.; Avihingsanon, Y.; Yee, V.C.; Tassaneeyakul, W.; Weinshilboum, R.M.
Thiopurine S-methyltransferase pharmacogenetics: Functional characterization of a novel rapidly degraded variant allozyme (2009), Biochem. Pharmacol., 79, 1053-1061.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in COS-1 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
Y107D	the mutant shows less than 10% activity compared to the wild type enzyme, the variant allozyme shows a striking decrease in both immunoreactive protein level and enzyme activity after transient expression in COS-1 cells, the mutant is less stable than the wild type TPMT allozyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P51580	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 6-mercaptopurine	-	Homo sapiens	S-adenosyl-L-homocysteine + 6-methylmercaptopurine	-	?

Synonyms

Synonyms	Comment	Organism
TPMT	-	Homo sapiens

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Release 2023.1 (January 2023)