Literature summary for 2.1.1.67 extracted from

Milek, M.; Karas Kuzelicki, N.; Smid, A.; Mlinaric-Rascan, I.
S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts (2009), Biochem. Pharmacol., 77, 1845-1853.

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Activating Compound

Activating Compound	Comment	Organism	Structure
S-adenosyl-L-methionine	S-adenosyl-L-methionine acts as a positive modulator of TPMT activity, the effect of S-adenosyl-L-methionine appears to be restricted to protein stabilisation rather than an increase of TPMT expression	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
6-Mercaptopurine	TPMT activity and protein levels are diminished in cells incubated with 6-mercaptopurine	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphoblast	-	Homo sapiens	-
MOLT cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 6-mercaptopurine	-	Homo sapiens	S-adenosyl-L-homocysteine + 6-methylmercaptopurine	-	?
S-adenosyl-L-methionine + thioinosine monophosphate	-	Homo sapiens	S-adenosyl-L-homocysteine + methylthioinosine monophosphate	-	?

Synonyms

Synonyms	Comment	Organism
thiopurine methyltransferase	-	Homo sapiens
TPMT	-	Homo sapiens

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Release 2023.1 (January 2023)