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Literature summary for 2.1.1.67 extracted from

  • Tamori, A.; Shinzaki, M.; Kosaka, S.; Hayashi, T.; Iwai, S.; Enomoto, M.; Habu, D.; Sakaguchi, H.; Kawada, N.; Hino, M.; Shiomi, S.; Nishiguchi, S.
    Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases (2007), Liver Int., 27, 95-100.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
diagnostics thiopurine S-methyltransferase genotypes or phenotypes may be a predictive factor for azathioprine-induced toxicities Homo sapiens

Protein Variants

Protein Variants Comment Organism
TPMT*2 polymorphism, single nucleotide substitution, G238C at codon 80 Homo sapiens
TPMT*3A polymorphism, single nucleotide substitutions, G460A at codon 154 and A719G at codon 240 Homo sapiens
TPMT*3B polymorphism, single nucleotide substitution, G460A at codon 154 Homo sapiens
TPMT*3C polymorphism, single nucleotide substitution, A719G at codon 240 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + azathioprine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine S-methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens