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Literature summary for 2.1.1.67 extracted from

  • Hamdan-Khalil, R.; Allorge, D.; Lo-Guidice, J.M.; Cauffiez, C.; Chevalier, D.; Spire, C.; Houdret, N.; Libersa, C.; Lhermitte, M.; Colombel, J.F.; Gala, J.L.; Broly, F.
    In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase (2003), Biochem. Biophys. Res. Commun., 309, 1005-1010.
    View publication on PubMed
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Application

Application Comment Organism
medicine the knowledge of the genetic basis of interindividual variability in thiopurine S-methyltransferase activity could enhance the efficiency of genotyping methods to preduct patients at risk of inadequate response to thiopurine therapy Homo sapiens
medicine the knowledge of the genetic basis of interindividual variability in thiopurine S-methyltransferase activity could enhance the efficiency of genotyping methods to product patients at risk of inadequate response to thiopurine therapy Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0349
-
 6-thioguanine
-
 Homo sapiens
0.0555
-
 6-thioguanine the Km-value of the variant Ser125Leu is 1.6fold higher than the Km-value of the wild-type variant, the ratio of Vmax to Km-value is 27% of the wild-type ratio Homo sapiens
0.0635
-
 6-thioguanine the Km-value of the variant Gly144Arg is 1.8fold higher than the Km-value of the wild-type variant, the ratio of Vmax to Km-value is 31% of the wild-type ratio Homo sapiens
0.0759
-
 6-thioguanine the Km-value of the variant Glu28Val is 2.2fold higher than the Km-value of the wild-type variant, the ratio of Vmax to KM-value is 58% of the wild-type ratio Homo sapiens
0.1799
-
 6-thioguanine the Km-value of the variant Gly144Arg is 5.1fold higher than the Km-value of the wild-type variant, the ratio of Vmax to KM-value is 10.4% of the wild-type ratio Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 natural variant Glu28Val, TPMT*13
-
Homo sapiens
-
 natural variant Gly144Arg, variant TPMT*10
-
Homo sapiens
-
 natural variant His227Gln, variant TPMT*7
-
Homo sapiens
-
 natural variant Ser125Leu, variant TPMT*12
-
Homo sapiens
-
 wild-type variant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?

Synonyms

Synonyms Comment Organism
TPMT
-
 Homo sapiens