Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,4-dimethoxy-5-hydroxybenzoic acid | - |
Homo sapiens | |
6-Mercaptopurine | - |
Homo sapiens | |
benzoic acid | benzoic acid derivatives | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00637 | - |
S-adenosyl-L-methionine | isoenzyme II | Homo sapiens | |
0.00722 | - |
S-adenosyl-L-methionine | isoenzyme I | Homo sapiens | |
0.224 | - |
6-Mercaptopurine | isoenzyme II | Homo sapiens | |
0.307 | - |
6-Mercaptopurine | isoenzyme I | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
2 isozymes, gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a thiopurine | Mus musculus | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse | - |
Purification (Comment) | Organism |
---|---|
2 isozymes | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Mus musculus | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + 6-mercaptopurine | immunosuppressant medication | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + 6-thioguanine | - |
Mus musculus | S-adenosyl-L-homocysteine + 6-methylthioguanine | - |
? | |
S-adenosyl-L-methionine + 6-thioguanine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylthioguanine | - |
? | |
S-adenosyl-L-methionine + a thiopurine | - |
Mus musculus | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00802 | - |
6-Mercaptopurine | isoenzyme II | Homo sapiens | |
0.0107 | - |
3,4-dimethoxy-5-hydroxybenzoic acid | isoenzyme II | Homo sapiens | |
0.0113 | - |
6-Mercaptopurine | isoenzyme I | Homo sapiens | |
0.0113 | - |
3,4-dimethoxy-5-hydroxybenzoic acid | isoenzyme I | Homo sapiens |