Literature summary for 2.1.1.63 extracted from

Yang, L.; Li, W.; Zhao, Y.; Zhong, S.; Wang, X.; Jiang, S.; Cheng, Y.; Xu, H.; Zhao, G.
Computational study of novel natural inhibitors targeting O6-methylguanine-DNA methyltransferase (2019), World Neurosurg., 130, e294-e306 .

Search for more literature for 2.1.1.63

Inhibitors

Inhibitors	Comment	Organism	Structure
2-hexaprenyl-6-methoxy-1,4-benzoquinone	-	Homo sapiens
methotrexate	-	Homo sapiens
O6-benzyl guanine	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine	Homo sapiens	-	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine	-	Homo sapiens	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-alkylguanine-DNA alkyltransferase	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)