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Literature summary for 2.1.1.63 extracted from

  • Kishida, Y.; Natsume, A.; Toda, H.; Toi, Y.; Motomura, K.; Koyama, H.; Matsuda, K.; Nakayama, O.; Sato, M.; Suzuki, M.; Kondo, Y.; Wakabayashi, T.
    Correlation between quantified promoter methylation and enzymatic activity of O6-methylguanine-DNA methyltransferase in glioblastomas (2012), Tumour Biol., 33, 373-381.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
O6-benzylguanine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
Homo sapiens
-
T-98 cell
-
Homo sapiens
-
U-251SP cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine
-
Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
?

Synonyms

Synonyms Comment Organism
AGT
-
Homo sapiens
MGMT
-
Homo sapiens
O6-methylguanine-DNA methyltransferase
-
Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65
-
the enzyme is inactivated after 5 min at 65°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00088
-
at pH 8.0 and 37°C Homo sapiens O6-benzylguanine