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Literature summary for 2.1.1.63 extracted from

  • Maxwell, J.A.; Johnson, S.P.; Quinn, J.A.; McLendon, R.E.; Ali-Osman, F.; Friedman, A.H.; Herndon, J.E.; Bierau, K.; Bigley, J.; Bigner, D.D.; Friedman, H.S.
    Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma (2006), Mol. Cancer Ther., 5, 2531-2539.
    View publication on PubMed

Application

Application Comment Organism
medicine highly significant correlation between AGT protein expression assessed by immunohistochemistry and AGT activity assessed by HPLC, marginal statistically significant correlation between immunohistochemistry and real-time methylation-specific PCR, and no significant correlation between AGT protein activity assessed by HPLC versus real-time methylation-specific PCR. Cross-tabulation of immunohistochemistry and real-time methylation-specific PCR data based on prognostic groups shows no significant relationship, suggesting that one assay cannot be used interchangeably for another, thus the results cannot be used to guide glioma therapy decisions Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information malignant glioma cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
?

Synonyms

Synonyms Comment Organism
AGT
-
Homo sapiens
O6-alkylguanine-DNA alkyltransferase
-
Homo sapiens