Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.63 extracted from

  • Povey, A.C.; ODonnell, P.; Barber, P.; Watson, M.; Margison, G.P.; Santibanez Koref, M.F.
    Smoking is associated with a decrease of O6-alkylguanine-DNA alkyltransferase activity in bronchial epithelial cells (2006), Int. J. Cancer, 119, 463-466.
    View publication on PubMed
Search for more literature for 2.1.1.63

Application

Application Comment Organism
medicine cigarette smoking not only induces O6-alkylguanine lesions, it inhibits the repair of these adducts by MGMT, O6-alkylguanine adducts are well established carcinogenic lesions and decreased repair of such lesions may increase susceptibility to lung cancer in smokers Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchial epithelial cell activity is significantly decreased in samples from current smokers compared to nonsmokers Homo sapiens
-
lung
-
 Homo sapiens
-
PBMC cell line MGMT activity is significantly lower in bronchial epithelial cells than in PBMC cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
MGMT
-
 Homo sapiens
O6-alkylguanine-DNA alkyltransferase
-
 Homo sapiens
O6-methylguanine-DNA methyltransferase
-
 Homo sapiens