Application | Comment | Organism |
---|---|---|
medicine | cigarette smoking not only induces O6-alkylguanine lesions, it inhibits the repair of these adducts by MGMT, O6-alkylguanine adducts are well established carcinogenic lesions and decreased repair of such lesions may increase susceptibility to lung cancer in smokers | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchial epithelial cell | activity is significantly decreased in samples from current smokers compared to nonsmokers | Homo sapiens | - |
lung | - |
Homo sapiens | - |
PBMC cell line | MGMT activity is significantly lower in bronchial epithelial cells than in PBMC cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MGMT | - |
Homo sapiens |
O6-alkylguanine-DNA alkyltransferase | - |
Homo sapiens |
O6-methylguanine-DNA methyltransferase | - |
Homo sapiens |