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Literature summary for 2.1.1.63 extracted from
- O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells (2007), Cancer Res., 67, 580-584.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibition of tumor suppressor p53 by RNAi is accompanied by down-regulation of MGMT gene expression, but is not associated with a discernible change in the pattern of MGMT promoter methylation | Homo sapiens |
| medicine | tumor suppressor p53 positively regulates MGMT gene expression in murine astrocytes | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
newborn C57bl/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Homo sapiens | - |
| astrocyte | MGMT gene expression is substantially lower in knockout p53 astrocytes than in wild-type p53 astrocytes | Mus musculus | - |
| cerebrum | - |
Mus musculus | - |
| glioma cell line | - |
Homo sapiens | - |
| SF-767 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MGMT | - |
Mus musculus |
| MGMT | - |
Homo sapiens |
| O6-methylguanine-DNA methyltransferase | - |
Mus musculus |
| O6-methylguanine-DNA methyltransferase | - |
Homo sapiens |
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