Application | Comment | Organism |
---|---|---|
medicine | O4-benzylfolic acid is 30times more active than O6-benzylguanine against the wild-type alkyltransferase, inactivation of P140K mutant alkyltransferase. Inhibitor shows promise as an agent for possible tumor-selective alkyltransferase inactivation superior toO6-benzylguanine as a chemotherapy adjuvant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-O4-benzyl-6,7-dimethylpteridine | potent | Homo sapiens | |
2-amino-O4-benzyl-6-formylpteridine | potent | Homo sapiens | |
2-amino-O4-benzyl-6-hydroxymethylpteridine | potent | Homo sapiens | |
2-amino-O4-benzylpteridine | potent | Homo sapiens | |
2-amino-O4-benzylpteridine-6-carboxylic acid | potent | Homo sapiens | |
O4-benzylfolic acid | 30times more active than O6-benzylguanine against the wild-type alkyltransferase, inactivation of P140K mutant alkyltransferase. Inhibitor shows promise as an agent for possible tumor-selective alkyltransferase inactivation superior toO6-benzylguanine as a chemotherapy adjuvant | Homo sapiens | |
O6-benzylguanine | potent inhibitor of wild-type enzyme, no inactivation of mutant enzyme P140K | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |