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Literature summary for 2.1.1.56 extracted from

  • Dunn, S.; Lombardi, O.; Lukoszek, R.; Cowling, V.H.
    Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells (2019), Open Biology, 9, 190052 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.56

Activating Compound

Activating Compound Comment Organism Structure
RNMT-activating miniprotein
-
 Homo sapiens

Application

Application Comment Organism
medicine the enzyme is a therapeutic target in breast cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] Homo sapiens the enzyme methylates the guanosine cap on the N-7 position to create the cap structure, m7G(5)ppp(5)X S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
BT-549 cell
-
 Homo sapiens
-
CAMA-1 cell
-
 Homo sapiens
-
HCC-1500 cell
-
 Homo sapiens
-
HCC-1569 cell
-
 Homo sapiens
-
HCC-1806 cell
-
 Homo sapiens
-
HCC-38 cell
-
 Homo sapiens
-
JIMT-1 cell
-
 Homo sapiens
-
mammary epithelial cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
NCI-H460 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-
ZR-75-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] the enzyme methylates the guanosine cap on the N-7 position to create the cap structure, m7G(5)ppp(5)X Homo sapiens S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA]
-
 ?

Subunits

Subunits Comment Organism
? x * 65000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
mRNA cap methyltransferase
-
 Homo sapiens
RNA guanine-7 methyltransferase
-
 Homo sapiens
RNMT
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction when cellular enzyme activity is experimentally reduced by 50%, the proliferation rate of nontransformed mammary epithelial cells is unchanged, whereas a subset of breast cancer cell lines exhibit reduced proliferation and increased apoptosis Homo sapiens