Literature summary for 2.1.1.56 extracted from

Sun, Y.; Wang, Z.; Tao, J.; Wang, Y; Wu, A; Yang, Z.; Wang, K.; Shi, L.; Chen, Y.; Guo, D.
Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase (2014), Antiviral Res., 104, 156-164.

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Application

Application	Comment	Organism
analysis	yeast-based system for identifying and screening inhibitors against coronavirus N7-MTase using both 96-well and 384-well microtiter plates. Sinefungin effectively suppressed N7-MTase in the yeast system. The results validate the yeast assay system for inhibitor screening yet also demonstrate the difference between cell-based and in vitro biochemical assays. The yeast system is applied to the screening of 3000 natural product extracts	Severe acute respiratory syndrome-related coronavirus

Inhibitors

Inhibitors	Comment	Organism	Structure
sinefungin	IC50 value 0.00169 microM in yeast cell-based assay	Severe acute respiratory syndrome-related coronavirus

Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome-related coronavirus	P0C6X7	-	-

Synonyms

Synonyms	Comment	Organism
N7-MTase	-	Severe acute respiratory syndrome-related coronavirus

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Release 2023.1 (January 2023)