Protein Variants | Comment | Organism |
---|---|---|
E1764A | mutation abolishes both guanine-N-7 (G-N-7) and ribose 2'-O methylation methylation | vesicular stomatitis virus |
F1691A | mutation abolishes both guanine-N-7 (G-N-7) and ribose 2'-O methylation. Alanine substitution results in recombinant virus that does not form plaques and significant diminished viral replication | vesicular stomatitis virus |
F1691W | mutation does not significantly affect the size of viral plaques. Mutant replicates as wild-type VSV. Mutant exhibits 82% of wild-type guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
F1691Y | mutation does not significantly affect the size of viral plaques. Mutant replicates as wild-type VSV. Mutant exhibits 85% of wild-type guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
F1745A | mutant shows a moderate defect in guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
F1816A | mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
L1757A | mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
N1692A | mutant shows a moderate defect in guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
P1709A | mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
S1693A | mutant shows a moderate defect in guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
S1827A | mutant shows a moderate defect in guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
W1744A | mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
Y1650A | mutation abolishes both guanine-N-7 (G-N-7) and ribose 2'-O methylation. Alanine substitution results in recombinant virus that does not form plaques and significant diminished viral replication | vesicular stomatitis virus |
Y1650F | mutation does not significantly affect the size of viral plaques. Mutant replicates as wild-type VSV. Mutant exhibits 88% of wild-type guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
Y1650W | mutation does not significantly affect the size of viral plaques. Mutant replicates as wild-type VSV. Mutant exhibits 90% of wild-type guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
Y1835A | mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation | vesicular stomatitis virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
vesicular stomatitis virus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + G(5')pppR-RNA | - |
vesicular stomatitis virus | S-adenosyl-L-homocysteine + m7G(5')pppR-RNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
guanine-N-7 methyltransferase | - |
vesicular stomatitis virus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
vesicular stomatitis virus |