BRENDA - Enzyme Database show
show all sequences of 2.1.1.56

Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n)

Selisko, B.; Peyrane, F.F.; Canard, B.; Alvarez, K.; Decroly, E.; J. Gen. Virol. 91, 112-121 (2010)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
sinefungin
-
Dengue virus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + G(5')pppR-RNA
Dengue virus
-
S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Dengue virus
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + G(5')pppR-RNA
-
704920
Dengue virus
S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
sinefungin
-
Dengue virus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + G(5')pppR-RNA
Dengue virus
-
S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + G(5')pppR-RNA
-
704920
Dengue virus
S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
-
-
?
Other publictions for EC 2.1.1.56
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733122
Sun
Yeast-based assays for the hig ...
SARS coronavirus
Antiviral Res.
104
156-164
2014
-
1
-
-
-
-
1
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
734586
Chen
Structure-function analysis of ...
SARS coronavirus
J. Virol.
87
6296-6305
2013
-
-
1
1
27
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
27
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735335
Jin
Characterization of the guanin ...
SARS coronavirus
Virus Res.
176
45-52
2013
-
-
-
-
18
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735240
Thillier
Synthesis of 5' cap-0 and cap- ...
Homo sapiens
RNA
18
856-868
2012
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704920
Selisko
Biochemical characterization o ...
Dengue virus
J. Gen. Virol.
91
112-121
2010
-
-
-
-
-
-
1
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721099
Chung
Higher catalytic efficiency of ...
Dengue virus
Virology
402
52-60
2010
-
-
-
-
-
-
2
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
721100
Dong
Biochemical and genetic charac ...
Dengue virus
Virology
405
568-578
2010
-
-
1
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
721101
Zhang
Identification of aromatic ami ...
vesicular stomatitis virus
Virology
408
241-252
2010
-
-
-
-
16
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701751
Milani
Flaviviral methyltransferase/R ...
Dengue virus, Wesselsbron virus
Antiviral Res.
83
28-34
2009
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
4
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706020
Cowling
Enhanced mRNA cap methylation ...
Homo sapiens
Oncogene
29
930-936
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
706535
Chen
Functional screen reveals SARS ...
SARS coronavirus
Proc. Natl. Acad. Sci. USA
106
3484-3489
2009
-
-
1
-
4
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690028
Zheng
Mutational analysis of vaccini ...
Vaccinia virus
RNA
14
2297-2304
2008
-
-
-
-
20
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
20
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705423
Dong
West Nile virus methyltransfer ...
West Nile virus
J. Virol.
82
4295-4307
2008
-
-
-
-
20
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
20
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
706721
Zheng
Structure-function analysis of ...
Vaccinia virus
RNA
14
696-705
2008
-
-
1
-
49
-
-
16
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
14
-
-
-
-
-
-
-
-
-
1
-
-
49
-
-
-
-
16
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
14
-
-
-
-
-
-
-
-
-
-
676231
Peyrane
High-yield production of short ...
Homo sapiens
Nucleic Acids Res.
35
e26
2007
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674701
Zheng
Mutational analysis of Encepha ...
Encephalitozoon cuniculi, Saccharomyces cerevisiae
J. Biol. Chem.
281
35904-35913
2006
-
2
2
1
45
-
3
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
2
-
2
2
-
1
45
-
2
3
-
2
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
677098
Hall
Characterization of a Trypanos ...
Trypanosoma brucei
RNA
12
488-497
2006
-
1
1
-
10
-
-
-
-
-
1
-
-
4
-
-
1
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
10
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677246
Schwer
Genetic analysis of poxvirus m ...
Vaccinia virus
Virology
352
145-156
2006
-
1
1
-
28
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
28
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
659939
Shafer
Human mRNA cap methyltransfera ...
Homo sapiens
Mol. Cell. Biol.
25
2644-2649
2005
-
-
1
-
1
-
-
-
2
-
-
1
-
3
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674439
Hausmann
Encephalitozoon cuniculi mRNA ...
Encephalitozoon cuniculi
J. Biol. Chem.
280
20404-20412
2005
-
-
1
1
38
-
4
3
-
-
1
-
-
2
-
-
1
-
-
-
-
1
5
1
-
-
-
-
1
1
-
1
-
-
4
-
-
1
1
1
38
-
4
4
-
3
-
-
1
-
-
-
-
1
-
-
-
1
5
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
659921
Fabrega
Structure and mechanism of mRN ...
Encephalitozoon cuniculi
Mol. Cell
13
77-89
2004
-
-
1
1
18
-
-
-
-
-
-
1
-
1
-
-
1
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
18
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485473
Li
Characterization of the Adomet ...
bamboo mosaic virus
J. Virol.
75
782-788
2001
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485470
Yokoska
Cloning and characterization o ...
Xenopus laevis
Biochem. Biophys. Res. Commun.
268
617-624
2000
-
-
1
-
-
-
-
-
-
-
3
3
-
3
-
-
-
1
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485471
Wen
Cap methyltransferase selectiv ...
Homo sapiens
Genes Dev.
14
2944-2949
2000
1
-
1
-
-
-
1
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485466
Ahola
Semliki forest virus mRNA capp ...
Semliki forest virus
EMBO J.
18
3164-3172
1999
-
-
1
-
-
-
-
-
-
-
-
-
-
6
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485465
Ramadevi
Capping and methylation of mRN ...
bluetongue virus
Proc. Natl. Acad. Sci. USA
95
13537-13542
1998
-
-
1
-
1
1
9
-
2
-
-
-
-
1
-
-
1
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
1
-
9
-
-
2
-
-
-
-
-
-
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485469
Tsukamoto
Cloning and characterization o ...
Homo sapiens, Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
251
27-34
1998
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
485472
Mao
Vaccinia virus mRNA (guanine-7 ...
Vaccinia virus
Biochemistry
35
6900-6910
1996
-
-
1
-
6
-
-
-
-
-
-
-
-
4
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485467
Higman
The mRNA (guanine-7-)methyltra ...
Vaccinia virus
J. Biol. Chem.
269
14974-14981
1994
-
-
1
-
-
-
1
5
-
-
2
-
-
1
-
-
1
1
-
-
1
-
4
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
5
-
-
2
-
-
-
-
1
-
-
1
-
4
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485468
Mao
Intrinsic RNA (guanine-7) meth ...
Vaccinia virus
J. Biol. Chem.
269
24472-24479
1994
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
1
1
-
-
1
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485455
Cong
Methyltransferase and subunit ...
Vaccinia virus
J. Biol. Chem.
267
16424-16429
1992
-
-
1
-
1
-
10
-
1
-
3
2
-
1
-
-
-
1
-
-
-
-
3
2
1
-
-
-
-
-
-
-
12
-
-
-
-
1
-
-
1
-
-
10
12
-
1
-
3
2
-
-
-
-
-
-
-
-
3
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
485456
Higman
The vaccinia virus mRNA (guani ...
Vaccinia virus
J. Biol. Chem.
267
16430-16437
1992
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
1
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485463
Guo
Interaction and mutual stabili ...
Vaccinia virus
Proc. Natl. Acad. Sci. USA
87
4023-4027
1990
-
-
1
-
-
1
-
-
-
-
3
3
-
1
-
-
1
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
3
3
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485451
Cross
Identification of a unique gua ...
Semliki forest virus
Virology
130
452-463
1983
-
-
-
-
-
1
1
-
1
-
-
1
-
3
-
-
-
-
-
1
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
-
-
-
1
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
485462
Locht
Partial purification and chara ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae VY1160
Eur. J. Biochem.
134
117-121
1983
-
-
-
-
-
-
5
1
-
4
1
-
-
2
-
-
1
-
-
1
1
1
2
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
1
-
4
1
-
-
-
-
1
-
1
1
1
2
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
485450
Pugh
Effects of S-adenosylhomocyste ...
Vaccinia virus
Biochemistry
21
1535-1541
1982
-
-
-
-
-
-
19
-
1
-
-
2
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
19
-
-
1
-
-
2
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485461
Goswami
2-5-Linked oligo(adenylic acid ...
Mus musculus, Vaccinia virus
J. Biol. Chem.
257
6867-6870
1982
-
-
-
-
-
-
4
-
1
-
-
-
-
2
-
-
2
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
2
-
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
485460
Germershausen
5 Cap methylation of homologou ...
Neurospora crassa
Biochem. Biophys. Res. Commun.
82
871-878
1978
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
2
-
1
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
2
-
1
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485464
Monroy
Purification of mRNA guanylylt ...
Vaccinia virus, Vaccinia virus WR
J. Biol. Chem.
253
4481-4489
1978
-
-
-
-
-
1
-
-
1
-
1
-
-
11
-
-
1
-
-
-
-
1
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
1
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
485459
Pugh
Inhibition of Newcastle diseas ...
Avian avulavirus 1
Biochemistry
16
3928-3932
1977
-
-
-
-
-
-
10
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485457
Ensinger
Modification of the 5 terminus ...
Homo sapiens
J. Biol. Chem.
251
5283-5291
1976
-
-
-
-
-
-
-
-
2
3
1
-
-
1
-
-
1
-
-
1
1
2
8
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
3
1
-
-
-
-
1
-
1
1
2
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
485458
Martin
mRNA guanylyltransferase and m ...
Vaccinia virus, Vaccinia virus WR
J. Biol. Chem.
251
7313-7321
1976
-
-
-
-
-
-
-
-
1
1
-
-
-
11
-
-
1
-
-
-
-
-
13
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
13
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485452
Martin
Purification of mRNA guanylylt ...
Vaccinia virus, Vaccinia virus WR
J. Biol. Chem.
250
9322-9329
1975
-
-
-
-
-
-
2
-
1
-
2
2
-
11
-
-
1
-
-
-
-
1
4
1
1
-
-
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
2
3
-
1
-
2
2
-
-
-
1
-
-
-
1
4
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
485453
Martin
Modification of RNA by mRNA gu ...
Vaccinia virus
J. Biol. Chem.
250
9330-9335
1975
-
-
-
-
-
-
6
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
6
-
-
1
1
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
485454
Ensinger
Modification of the 5-terminus ...
Vaccinia virus
Proc. Natl. Acad. Sci. USA
72
2525-2529
1975
-
-
-
-
-
-
2
-
1
2
-
-
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
2
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-