Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(RS)-2-amino-4-[(2-carboxyethylthio)methylthio]butanoic acid | 97.6% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-amino-4-[(3-carboxypropyl)disulfanyl]butanoic acid | 19.1% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-amino-4-[2-(carboxymethylamino)ethylthio]butanoic acid | 37.1% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-amino-4-[2-(R)-(1-carboxyethylamino)ethylthio]butanoic acid | 15.5% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-amino-4-[2-(S)-(1-carboxyethylamino)ethylthio]butanoic acid | 19.8% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-amino-4-[2-[(carboxymethyl)(methyl)amino]ethylthio]-butanoic acid | 98.5% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-amino-4-[3-[(carboxymethyl)(methyl)amino]propylthio]butanoic acid | 79.01% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-amino-5-(3-carboxypropylthio)pentanoic acid | 5.4% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-aminodecanedioic acid | 2.11% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-[[2-(3-amino-3-carboxypropylthio)ethyl]dimethylammonium]acetate | 23.8% inhibition at 0.02 mM | Homo sapiens | |
(RS)-2-[[3-(3-amino-3-carboxypropylthio)propyl]dimethylammonio]acetate | 3.3% inhibition at 0.02 mM | Homo sapiens | |
(RS)-5-(3-amino-3-carboxypropoxy)pentanoic acid | 9.8% inhibition at 0.02 mM | Homo sapiens | |
(RS)-5-(3-amino-3-carboxypropylselanyl)pentanoic acid | complete inhibition at 0.02 mM | Homo sapiens | |
(RS)-5-(3-amino-3-carboxypropylthio)-3,3-dimethylpentanoic acid | highly potent inhibitor of BHMT, complete inhibition at 0.02 mM | Homo sapiens | |
(RS)-5-(3-amino-3-carboxypropylthio)-3-methylpentanoic acid | highly potent inhibitor of BHMT, complete inhibition at 0.02 mM | Homo sapiens | |
5-[(3-amino-3-carboxypropyl)sulfanyl]pentanoic acid | complete inhibition at 0.02 mM | Homo sapiens | |
additional information | not inhibited by (RS)-2-[[(3-amino-3-carboxypropylthio)methyl]dimethylammonium] acetate and (RS)-2-amino-4-[2-(2-carboxyethylamino)ethylthio]butanoic acid | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-homocysteine + betaine | - |
Homo sapiens | L-methionine + dimethylglycine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BHMT | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000084 | - |
in 50 mM potassium phosphate buffer, at pH 7.5, at 37°C | Homo sapiens | (RS)-5-(3-amino-3-carboxypropylthio)-3,3-dimethylpentanoic acid | |
0.000139 | - |
in 50 mM potassium phosphate buffer, at pH 7.5, at 37°C | Homo sapiens | (RS)-5-(3-amino-3-carboxypropylthio)-3-methylpentanoic acid | |
0.000649 | - |
in 50 mM potassium phosphate buffer, at pH 7.5, at 37°C | Homo sapiens | (RS)-5-(3-amino-3-carboxypropylselanyl)pentanoic acid | |
0.0025 | - |
in 50 mM potassium phosphate buffer, at pH 7.5, at 37°C | Homo sapiens | (RS)-2-amino-4-[2-[(carboxymethyl)(methyl)amino]ethylthio]-butanoic acid | |
0.00326 | - |
in 50 mM potassium phosphate buffer, at pH 7.5, at 37°C | Homo sapiens | (RS)-2-amino-4-[(2-carboxyethylthio)methylthio]butanoic acid |