Literature summary for 2.1.1.5 extracted from

Mercer, C.; Kaliappan, A.; Dennis, P.
Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization (2008), Autophagy, 4, 185-194.

Search for more literature for 2.1.1.5

Cloned(Commentary)

Cloned (Comment)	Organism
glutathione S-transferase-BHMT fusion protein is expressed in HEK-293, T98G, A-10, MCF-7, H-1299, C2C12, and NIH-3T3 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C217A	the mutation reduces zinc binding by 95% while abrogating catalytic activity, the mutation has no effect on the fold increase of GST-BHMT proteolytic fragment in the absence of nutrients	Homo sapiens
W352A	the mutation disrupts stable BHMT multimerization, the mutant ablates catalytic activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-homocysteine + betaine	-	Homo sapiens	L-methionine + dimethylglycine	-	?

Subunits

Subunits	Comment	Organism
tetramer	-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
betaine homocysteine methyltransferase	-	Homo sapiens
BHMT	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	betaine homocysteine methyltransferase is a potential cargo-based end-point marker for macroautophagy	Homo sapiens

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Release 2023.1 (January 2023)