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Literature summary for 2.1.1.5 extracted from

  • Szegedi, S.S.; Garrow, T.A.
    Oligomerization is required for betaine-homocysteine S-methyltransferase function (2004), Arch. Biochem. Biophys., 426, 32-42.
    View publication on PubMed
Search for more literature for 2.1.1.5

Protein Variants

Protein Variants Comment Organism
DELTA325-406 truncation mutatnt does not express well in Escherichia coli and is inactive Homo sapiens
DELTA371-406 truncation mutant does not express well in Escherichia coli and is inactive Homo sapiens
E266A near-normal catalytic activity Homo sapiens
H338A normal or near-normal ability to bind zinc, 10% of the wild-type activity Homo sapiens
N364A normal or near-normal ability to bind zinc, near-normal catalytic activity Homo sapiens
P362A normal or near-normal ability to bind zinc, near-normal catalytic activity Homo sapiens
P365A normal or near-normal ability to bind zinc, near-normal catalytic activity Homo sapiens
R346A normal or near-normal ability to bind zinc, negligible activity, elution as dimer, aberrant crosslinking properties Homo sapiens
R361A normal or near-normal ability to bind zinc, near-normal catalytic activity Homo sapiens
W352A negligible activity, elution as dimer, aberrant crosslinking properties Homo sapiens
Y363A normal or near-normal ability to bind zinc, near-normal catalytic activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc wild-type enzyme contains zinc. Mutant enzymes H338A, R346A, W352A, R361A, P362A, Y363A, N364A, P365A maintain normal or near-normal ability to bind zinc Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q93088 recombinant enzyme
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Subunits

Subunits Comment Organism
dimer mutant enzmyes R346A and W352A with negligible activity Homo sapiens
tetramer wild-type enzyme and mutant enzymes E266A, H338A, R346A, R361A, P362A, N364A and P365A Homo sapiens