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Literature summary for 2.1.1.5 extracted from

  • Lee, K.H.; Cava, M.; Amiri, P.; Ottoboni, T.; Lindquist, R.N.
    Betaine:homocysteine methyltransferase from rat liver: purification and inhibition by a boronic acid substrate analog (1992), Arch. Biochem. Biophys., 292, 77-86.
    View publication on PubMed

General Stability

General Stability Organism
glycerol does not stabilize Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Pinanyl N,N,N-trimethylaminomethane boronate substrate analogue Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
L-homocysteine betaine Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
6 * 45000, SDS-PAGE Rattus norvegicus
270000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-

Purification (Commentary)

Purification (Comment) Organism
FPLC-chromatofocusing, 3 active forms Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0187
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, 2 weeks in the presence of substrates Rattus norvegicus
-20°C, 40% loss of activity after 4 weeks in the presence of substrates Rattus norvegicus
-20°C, 70% loss of activity after 10 weeks in the presence of substrates Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N,N,N-trimethylglycine + L-homocysteine
-
Rattus norvegicus N,N-dimethylglycine + L-methionine
-
?
N,N,N-trimethylglycine + L-homocysteine
-
Rattus norvegicus Sprague-Dawley N,N-dimethylglycine + L-methionine
-
?

Subunits

Subunits Comment Organism
hexamer 6 * 45000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
3 active forms with pI: 7.0, 7.6 and 8.0 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.045
-
Pinanyl N,N,N-trimethylaminomethane boronate
-
Rattus norvegicus