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Literature summary for 2.1.1.49 extracted from
- Multiple N-methyltransferases for aromatic alkylamines in brain (1973), Life Sci., 13, 847-858.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 6.25 | - |
beta-phenylethylamine | 5-methyltetrahydrofolate as methyl donor | Rattus norvegicus |  |
| 8.3 | - |
tryptamine | 5-methyltetrahydrofolate as methyl donor | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley strain male rats | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00000038 | - |
beta-phenylethylamine + S-adenosyl-L-methionine | Rattus norvegicus |
| 0.00000118 | - |
tryptamine + S-adenosyl-L-methionine | Rattus norvegicus |
| 0.000065 | - |
beta-phenylethylamine + 5-methyltetrahydrofolate | Rattus norvegicus |
| 0.000198 | - |
tryptamine + 5-methyltetrahydrofolate | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + alpha-N-methyltryptamine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine | N,N-dimethyltryptamine as product | ? | |
| S-adenosyl-L-methionine + beta-phenylethylamine | 5-methyltetrahydrofolate can replace S-adenosyl-L-methionine as methyl donor | Rattus norvegicus | ? | - |
? | |
| S-adenosyl-L-methionine + tryptamine | two N-methyltransferases, non-specific or specific for tryptamine, 5-methyltetrahydrofolate can replace S-adenosyl-L-methionine as methyl donor | Rattus norvegicus | S-adenosyl-L-homocysteine + alpha-N-methyltryptamine | - |
? | |
| S-adenosyl-L-methionine + tryptamine | i.e. 3-[2-aminoethyl] indole, best substrate, two N-methyltransferases: A and B, non-specific | Rattus norvegicus | S-adenosyl-L-homocysteine + alpha-N-methyltryptamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aromatic alkylamine-N-methyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7 | 5-methyltetrahydrofolate as donor | Rattus norvegicus |
| 7.9 | - |
S-adenosyl-L-methionine as donor | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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