Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone | Glycyrrhiza uralensis | - |
S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone | - |
? | |
S-adenosyl-L-methionine + daidzein | Glycyrrhiza uralensis | - |
S-adenosyl-L-homocysteine + formononetin | - |
? | |
S-adenosyl-L-methionine + genistein | Glycyrrhiza uralensis | - |
S-adenosyl-L-homocysteine + biochanin A | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Glycyrrhiza uralensis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Glycyrrhiza uralensis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the bifunctionally enzyme also catalyzes the formation of a 2,7-dihydroxy-4'-methoxyisoflavanone from a 2,4',7-trihydroxyisoflavanone (reaction of EC 2.1.1.212) | Glycyrrhiza uralensis | ? | - |
- |
|
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone | - |
Glycyrrhiza uralensis | S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone | - |
? | |
S-adenosyl-L-methionine + daidzein | - |
Glycyrrhiza uralensis | S-adenosyl-L-homocysteine + formononetin | - |
? | |
S-adenosyl-L-methionine + genistein | - |
Glycyrrhiza uralensis | S-adenosyl-L-homocysteine + biochanin A | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase/isoflavone 4'-O-methyltransferase | - |
Glycyrrhiza uralensis |
HI4OMT | - |
Glycyrrhiza uralensis |
More | see also EC 2.1.1.212 | Glycyrrhiza uralensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Glycyrrhiza uralensis |
General Information | Comment | Organism |
---|---|---|
evolution | a synteny block among Cicer arietinum chromosome 6 (inverted), Glycyrrhiza uralensis scaffold 00721 and Medicago truncatula chromosome 4, which includes genes involved in isoflavonoid biosynthesis (7-IOMT, CYP93C and HI4OMT), overview | Glycyrrhiza uralensis |
metabolism | the enzyme is involved in the isoflavonoid biosynthesis together with 2-hydroxyisoflavanone synthase (CYP93C) and isoflavone-7-O-methyltransferase (7-IOMT), forming a cluster on the scaffold of the liquorice genome. The second gene in the cluster encodes the enzyme 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase/isoflavone 4'-O-methyltransferase, i.e. HI4OMT (ECs 2.1.1.212 and 2.1.1.46), which typically converts daidzein to formononetin or genistein to biochanin A | Glycyrrhiza uralensis |