Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.46 extracted from

  • Mochida, K.; Sakurai, T.; Seki, H.; Yoshida, T.; Takahagi, K.; Sawai, S.; Uchiyama, H.; Muranaka, T.; Saito, K.
    Draft genome assembly and annotation of Glycyrrhiza uralensis, a medicinal legume (2017), Plant J., 89, 181-194 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone Glycyrrhiza uralensis
-
S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone
-
?
S-adenosyl-L-methionine + daidzein Glycyrrhiza uralensis
-
S-adenosyl-L-homocysteine + formononetin
-
?
S-adenosyl-L-methionine + genistein Glycyrrhiza uralensis
-
S-adenosyl-L-homocysteine + biochanin A
-
?

Organism

Organism UniProt Comment Textmining
Glycyrrhiza uralensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Glycyrrhiza uralensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the bifunctionally enzyme also catalyzes the formation of a 2,7-dihydroxy-4'-methoxyisoflavanone from a 2,4',7-trihydroxyisoflavanone (reaction of EC 2.1.1.212) Glycyrrhiza uralensis ?
-
-
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone
-
Glycyrrhiza uralensis S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone
-
?
S-adenosyl-L-methionine + daidzein
-
Glycyrrhiza uralensis S-adenosyl-L-homocysteine + formononetin
-
?
S-adenosyl-L-methionine + genistein
-
Glycyrrhiza uralensis S-adenosyl-L-homocysteine + biochanin A
-
?

Synonyms

Synonyms Comment Organism
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase/isoflavone 4'-O-methyltransferase
-
Glycyrrhiza uralensis
HI4OMT
-
Glycyrrhiza uralensis
More see also EC 2.1.1.212 Glycyrrhiza uralensis

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Glycyrrhiza uralensis

General Information

General Information Comment Organism
evolution a synteny block among Cicer arietinum chromosome 6 (inverted), Glycyrrhiza uralensis scaffold 00721 and Medicago truncatula chromosome 4, which includes genes involved in isoflavonoid biosynthesis (7-IOMT, CYP93C and HI4OMT), overview Glycyrrhiza uralensis
metabolism the enzyme is involved in the isoflavonoid biosynthesis together with 2-hydroxyisoflavanone synthase (CYP93C) and isoflavone-7-O-methyltransferase (7-IOMT), forming a cluster on the scaffold of the liquorice genome. The second gene in the cluster encodes the enzyme 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase/isoflavone 4'-O-methyltransferase, i.e. HI4OMT (ECs 2.1.1.212 and 2.1.1.46), which typically converts daidzein to formononetin or genistein to biochanin A Glycyrrhiza uralensis