Literature summary for 2.1.1.45 extracted from

Dowiercial, A.; Jarmula, A.; Wilk, P.; Rypniewski, W.; Kowalska, M.; Fraczyk, T.; Ciesla, J.; Rode, W.
Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme (2017), Struct. Chem., 28, 667-674 .

No PubMed abstract available

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complexes with sulfate anion, 2'-deoxyuridine 50-monophosphate and 5-fluorodUMP and N5,10-methylenetetrahydrofolate. The loop 175-191, homologous to human TS loop 181-197, populates the active conformer, with catalytic Cys 189 buried in the active site and directed toward C(6) of the pyrimidine ring of dUMP/FdUMP	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P07607	-	-

Synonyms

Synonyms	Comment	Organism
TYMS	-	Mus musculus

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Release 2023.1 (January 2023)