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Literature summary for 2.1.1.45 extracted from

  • Swiderek, K.; Kohen, A.; Moliner, V.
    The influence of active site conformations on the hydride transfer step of the thymidylate synthase reaction mechanism (2015), Phys. Chem. Chem. Phys., 17, 30793-30804.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A884
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information chemical conversion takes place preferentially via a concerted mechanism where the hydride transfer is conjugated to thiol-elimination from the product. The substrate-enzyme covalent bond established between the C6 of the nucleotide substrate and a conserved cysteine residue is of labile character Escherichia coli ?
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Synonyms

Synonyms Comment Organism
ThyA
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Escherichia coli