Inhibitors | Comment | Organism | Structure |
---|---|---|---|
10-propargyl-5,8-dideazafolate | - |
Escherichia coli | |
10-propargyl-5,8-dideazafolate | - |
Homo sapiens | |
10-propargyl-5,8-dideazafolate | - |
Toxoplasma gondii | |
2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
4-amino-N10-methylfolic acid | - |
Escherichia coli | |
4-amino-N10-methylfolic acid | - |
Homo sapiens | |
4-amino-N10-methylfolic acid | - |
Toxoplasma gondii | |
methotrexate | - |
Escherichia coli | |
methotrexate | - |
Homo sapiens | |
methotrexate | - |
Toxoplasma gondii | |
N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | - |
Escherichia coli | |
N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | - |
Homo sapiens | |
N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | - |
Toxoplasma gondii | |
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | potent inhibitor of thymidylate synthase | Escherichia coli | |
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | potent inhibitor of thymidylate synthase | Homo sapiens | |
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | potent inhibitor of thymidylate synthase | Toxoplasma gondii | |
pemetrexed | - |
Escherichia coli | |
pemetrexed | - |
Homo sapiens | |
pemetrexed | - |
Toxoplasma gondii | |
piritrexim | - |
Escherichia coli | |
piritrexim | - |
Homo sapiens | |
piritrexim | - |
Toxoplasma gondii | |
plevitrexed | - |
Escherichia coli | |
plevitrexed | - |
Homo sapiens | |
plevitrexed | - |
Toxoplasma gondii | |
raltitrexed | - |
Escherichia coli | |
raltitrexed | - |
Homo sapiens | |
raltitrexed | - |
Toxoplasma gondii | |
trimethoprim | - |
Escherichia coli | |
trimethoprim | - |
Homo sapiens | |
trimethoprim | - |
Toxoplasma gondii | |
trimetrexate | - |
Escherichia coli | |
trimetrexate | - |
Homo sapiens | |
trimetrexate | - |
Toxoplasma gondii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Toxoplasma gondii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Toxoplasma gondii | dihydrofolate + dTMP | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
N5,N10-methylenetetrahydrofolate | - |
Escherichia coli | |
N5,N10-methylenetetrahydrofolate | - |
Homo sapiens | |
N5,N10-methylenetetrahydrofolate | - |
Toxoplasma gondii |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000018 | - |
- |
Escherichia coli | N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | |
0.000019 | - |
- |
Escherichia coli | 10-propargyl-5,8-dideazafolate | |
0.000036 | - |
- |
Toxoplasma gondii | N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | |
0.00004 | - |
- |
Escherichia coli | N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | |
0.00004 | - |
- |
Homo sapiens | N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | |
0.000054 | - |
- |
Homo sapiens | N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | |
0.000085 | - |
- |
Homo sapiens | 10-propargyl-5,8-dideazafolate | |
0.00009 | - |
- |
Toxoplasma gondii | N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | |
0.00022 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
0.00023 | - |
- |
Homo sapiens | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.00028 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.00038 | - |
- |
Homo sapiens | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.00039 | - |
- |
Homo sapiens | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.00043 | - |
- |
Toxoplasma gondii | 10-propargyl-5,8-dideazafolate | |
0.00069 | - |
- |
Homo sapiens | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | |
0.00075 | - |
- |
Homo sapiens | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.001 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
0.001 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0011 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0011 | - |
- |
Homo sapiens | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0012 | - |
- |
Escherichia coli | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | |
0.0012 | - |
- |
Homo sapiens | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0013 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0014 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0016 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | |
0.0017 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0017 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0018 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0018 | - |
- |
Escherichia coli | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.002 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.002 | - |
- |
Escherichia coli | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0022 | - |
- |
Toxoplasma gondii | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0022 | - |
- |
Escherichia coli | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0022 | - |
- |
Toxoplasma gondii | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0023 | - |
- |
Escherichia coli | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0023 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0023 | - |
- |
Escherichia coli | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0023 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0025 | - |
- |
Escherichia coli | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0025 | - |
- |
Toxoplasma gondii | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0026 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0028 | - |
- |
Toxoplasma gondii | pemetrexed | |
0.0029 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0046 | - |
- |
Homo sapiens | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0056 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0084 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0095 | - |
- |
Homo sapiens | pemetrexed | |
0.023 | - |
IC50 above 0.023 mM | Escherichia coli | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.023 | - |
IC50 above 0.023 mM | Toxoplasma gondii | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.028 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.076 | - |
- |
Escherichia coli | pemetrexed |