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Literature summary for 2.1.1.45 extracted from

  • Giudice, S.; Benassi, L.; Bertazzoni, G.; Costi, M.P.; Gelain, A.; Venturelli, A.; Bernardi, C.; Gualdi, G.; Coppi, A.; Rossi, T.; Giannetti, A.; Magnoni, C.
    New thymidylate synthase inhibitors induce apoptosis in melanoma cell lines (2007), Toxicol. in Vitro, 21, 240-248.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,3-bis(4-methoxyphenyl)-1H,3H-benzo[de]isochromen-1-one induces apoptotic cell death in SK-MEL-2 and SK-MEL-28 melanoma cell lines, mediated by downregulation of Bcl-2 protein level and PARP cleavage, and independent of p53 and Bax. Pan-caspases inhibitor Z-VAD-FMK blocks the effect Homo sapiens
6-bromo-3,3-bis(3-chloro-4-hydroxyphenyl)-1H,3H-benzo[de]isochromen-1-one induces apoptotic cell death in SK-MEL-2 and SK-MEL-28 melanoma cell lines, mediated by downregulation of Bcl-2 protein level and PARP cleavage, and independent of p53 and Bax. Pan-caspases inhibitor Z-VAD-FMK blocks the effect Homo sapiens
6-chloro-3,3-bis(4-hydroxyphenyl)-1H,3H-benzo[de]isochromen-1-one induces apoptotic cell death in SK-MEL-2 and SK-MEL-28 melanoma cell lines, mediated by downregulation of Bcl-2 protein level and PARP cleavage, and independent of p53 and Bax. Pan-caspases inhibitor Z-VAD-FMK blocks the effect Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
SK-MEL-2 cell
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Homo sapiens
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SK-MEL-28 cell derived from primary malignant melanoma Homo sapiens
-