Literature summary for 2.1.1.45 extracted from

Mertes, M.P.; Chang, C.T.C.; de Clercq, E.; Huang, G.F.; Torrence, P.F.
5-Nitro-2-deoxyuridine 5-monophosphate is a potent irreversible inhibitor of Lactobacillus caesi thymidylate synthetase (1978), Biochem. Biophys. Res. Commun., 84, 1054-1059.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5-fluoro-2'-deoxyuridine 5'-monophosphate	-	Lacticaseibacillus casei
5-fluoro-2'-deoxyuridylic acid	-	Lacticaseibacillus casei
5-iodo-2'-deoxyuridylic acid	-	Lacticaseibacillus casei
5-Nitro-2'-deoxyuridine 5'-monophosphate	-	Lacticaseibacillus casei
5-nitro-2'-deoxyuridylic acid	-	Lacticaseibacillus casei
5-trifluoromethyl-2'-deoxyuridine 5'-monophosphate	-	Lacticaseibacillus casei

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0015	-	2'-deoxyuridine 5'-monophosphate	-	Lacticaseibacillus casei

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP	Lacticaseibacillus casei	-	dihydrofolate + dTMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Lacticaseibacillus casei	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Lacticaseibacillus casei

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP	-	Lacticaseibacillus casei	dihydrofolate + dTMP	-	?
5,10-methylenetetrahydrofolate + dUMP	-	Lacticaseibacillus casei	dihydrofolate + dTMP	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000014	-	5-fluoro-2'-deoxyuridine 5'-monophosphate	-	Lacticaseibacillus casei
0.000029	-	5-Nitro-2'-deoxyuridine 5'-monophosphate	-	Lacticaseibacillus casei
0.000039	-	5-trifluoromethyl-2'-deoxyuridine 5'-monophosphate	-	Lacticaseibacillus casei

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Release 2023.1 (January 2023)