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Literature summary for 2.1.1.41 extracted from

  • Mukherjee, S.; Xu, W.; Hsu, F.; Patel, J.; Huang, J.; Zhang, K.
    Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major (2019), Mol. Microbiol., 111, 65-81 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.41

Localization

Localization Comment Organism GeneOntology No. Textmining
endocytic vesicle
-
 Leishmania major 30139
-
endoplasmic reticulum
-
 Leishmania major 5783
-

Organism

Organism UniProt Comment Textmining
Leishmania major Q4Q1I2
-
-
Leishmania major Q4Q1I3
-
-

Synonyms

Synonyms Comment Organism
LMJF_36_2380
-
 Leishmania major
LMJF_36_2390
-
 Leishmania major
SMT80
-
 Leishmania major
SMT90
-
 Leishmania major

General Information

General Information Comment Organism
physiological function deletion of both isoforms SMT80 and SMT90 leads to a complete loss of C24-methylated sterols, which are replaced by cholestane-based sterols. SMT-null mutants are fully viable and replicative in culture but show increased sensitivity to sphingolipid synthesis inhibition. They are not particularly vulnerable to heat, acidic pH, nitrosative or oxidative stress, yet exhibit high mitochondrial membrane potential and increased superoxide generation. Mutants possess high levels of GPI-anchored glycoconjugates, but show significantly attenuated virulence in mice Leishmania major