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Literature summary for 2.1.1.41 extracted from

  • Mo, C.; Valachovic, M.; Bard, M.
    The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p) (2004), Biochim. Biophys. Acta, 1686, 30-36.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
zymosterol + S-adenosyl-L-methionine Saccharomyces cerevisiae the enzyme catalyzes an enzymatic step following C-4 demethylation of 4,4-dimethylzymosterol. Erg28p anchors the C-4 demethylation enzyme complex to the endoplasmic reticulum and acts as a protein bridge to the Erg6p enzyme required for the next ergisterol biosynthetic step fecosterol + S-adenosyl-L-homocysteine
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
zymosterol + S-adenosyl-L-methionine the enzyme catalyzes an enzymatic step following C-4 demethylation of 4,4-dimethylzymosterol. Erg28p anchors the C-4 demethylation enzyme complex to the endoplasmic reticulum and acts as a protein bridge to the Erg6p enzyme required for the next ergisterol biosynthetic step Saccharomyces cerevisiae fecosterol + S-adenosyl-L-homocysteine
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Synonyms

Synonyms Comment Organism
C-24 sterol methyltransferase
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Saccharomyces cerevisiae
Erg6p
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Saccharomyces cerevisiae