Literature summary for 2.1.1.41 extracted from

Acuna-Johnson, A.P.; Oehlschlager, A.C.; Pierce, A.M.; Pierce, H.D., Jr.; Czyzewska, E.K.
Stereochemistry of yeast DELTA24-sterol methyl transferase (1997), Bioorg. Med. Chem., 5, 821-832.

Search for more literature for 2.1.1.41

Inhibitors

Inhibitors	Comment	Organism	Structure
(24R)-methyl-25-thiacholesteryl iodide	-	Saccharomyces cerevisiae
(24S)-methyl-25-thiacholesteryl iodide	-	Saccharomyces cerevisiae
25-thiacholesterol iodide	-	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
zymosterol + S-adenosyl-L-methionine	Saccharomyces cerevisiae	-	fecosterol + S-adenosyl-L-homocysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	strain A184D erg+ and sterol mutant strain +erg2	-

Reaction

Reaction	Comment	Organism	Reaction ID
S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol	mechanism	Saccharomyces cerevisiae	a
S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol	kinetic and inhibition mechanism	Saccharomyces cerevisiae	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
zymosterol + S-adenosyl-L-methionine	-	Saccharomyces cerevisiae	fecosterol + S-adenosyl-L-homocysteine	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000011	-	25-thiacholesterol iodide	versus S-adenosyl-L-methionine	Saccharomyces cerevisiae
0.0000017	-	(24R)-methyl-25-thiacholesteryl iodide	versus S-adenosyl-L-methionine	Saccharomyces cerevisiae
0.0000023	-	(24S)-methyl-25-thiacholesteryl iodide	versus S-adenosyl-L-methionine	Saccharomyces cerevisiae
0.0000024	-	25-thiacholesterol iodide	versus zymosterol	Saccharomyces cerevisiae
0.000003	-	(24R)-methyl-25-thiacholesteryl iodide	versus zymosterol	Saccharomyces cerevisiae
0.0000046	-	(24S)-methyl-25-thiacholesteryl iodide	versus zymosterol	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)