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Literature summary for 2.1.1.41 extracted from

  • Nes, W.D.; Guo, D.a.; Zhou, W.
    Substrate-based inhibitors of the (S)-adenosyl-L-methionine: DELTA24(25)- to DELTA24(28)-sterol methyltransferase from Saccharomyces cerevisiae (1997), Arch. Biochem. Biophys., 342, 68-81.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information overview, diverse substrate and transition state analogues Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
zymosterol + S-adenosyl-L-methionine Saccharomyces cerevisiae
-
fecosterol + S-adenosyl-L-homocysteine
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol mechanism Saccharomyces cerevisiae
S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol kinetic and inhibition mechanism Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
zymosterol + S-adenosyl-L-methionine
-
Saccharomyces cerevisiae fecosterol + S-adenosyl-L-homocysteine
-
?
zymosterol + S-adenosyl-L-methionine
-
Saccharomyces cerevisiae fecosterol + S-adenosyl-L-homocysteine fecosterol is 24-exomethylene-5alpha-cholesta-8,24-dien-3beta-ol ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information overview, diverse substrate and transition state analogues Saccharomyces cerevisiae