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Literature summary for 2.1.1.4 extracted from

  • Wang, L.; Zhang, T.; Li, J.; He, C.; He, H.; Zhang, J.
    Catalytic mechanism of human N-acetylserotonin methyltransferase: a theoretical investigation (2015), Mol. Phys., 113, 3438-3449.
No PubMed abstract available
Search for more literature for 2.1.1.4

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme crystal structure, PDB ID 4A6E, analysis and structure modeling Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + N-acetylserotonin Homo sapiens
-
 S-adenosyl-L-homocysteine + melatonin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P46597
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin modeling of the catalytic mechanism Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + N-acetylserotonin
-
 Homo sapiens S-adenosyl-L-homocysteine + melatonin
-
 ?

Synonyms

Synonyms Comment Organism
ASMT
-
 Homo sapiens
HIOMT
-
 Homo sapiens
hydroxyindole O-methyltransferase
-
 Homo sapiens
N-acetylserotonin methyltransferase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens

General Information

General Information Comment Organism
evolution the enzyme belongs to S-adenosyl-L-methionine dependent animal natural product O-methyltransferase Homo sapiens
malfunction lack of melatonin is a risk signal and will result in diabetes, psychiatric disorders, and other diverse medical conditions Homo sapiens
metabolism ASMT is a key enzyme to catalyse the terminal step of melatonin (N-acetyl-5-methoxytryptamine) Homo sapiens
additional information roles of several residues around the active sites and methyl-transfer mechanism of human N-acetylserotonin methyltransferase, density function theory method, overview. residues H255, D256, E311, and R252 play an important role in reducing the barrier height and inducing methyl transfer. Some residues around the SAM in the centre of active site are essential factors to influence the mechanism and barrier height Homo sapiens
physiological function ASMT is a key enzyme to catalyse the terminal step of melatonin (N-acetyl-5-methoxytryptamine). Melatonin is related with various physiological functions, such as sleep induction, circadian rhythm regulation together with oxidative stress and immune response Homo sapiens