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Literature summary for 2.1.1.4 extracted from

  • Sanchez-Hidalgo, M.; de la Lastra, C.A.; Carrascosa-Salmoral, M.P.; Naranjo, M.C.; Gomez-Corvera, A.; Caballero, B.; Guerrero, J.M.
    Age-related changes in melatonin synthesis in rat extrapineal tissues (2009), Exp. Gerontol., 44, 328-334.
    View publication on PubMed
Search for more literature for 2.1.1.4

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
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kidney
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 Rattus norvegicus
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liver highest activity in liver Rattus norvegicus
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spleen lowest activity in spleen Rattus norvegicus
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thymus
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetylserotonin + S-adenosyl-L-methionine
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 Rattus norvegicus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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 ?

Synonyms

Synonyms Comment Organism
HIOMT
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 Rattus norvegicus
hydroxyindole-O-methyltransferase
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 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus there is an age-related decline in rat extrapineal melatonin synthesis with a consequent HIOMT functionality decrease in spleen, liver and heart during physiological aging, in the thymus HIOMT expression reveals no significant alterations with age down

General Information

General Information Comment Organism
metabolism HIOMT is a key enzyms involved in melatonin synthesis Rattus norvegicus