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Literature summary for 2.1.1.4 extracted from

  • Sugden, D.; Cena, V.; Klein, D.C.
    Hydroxyindole O-methyltransferase (1987), Methods Enzymol., 142, 590-596.
    View publication on PubMed
Search for more literature for 2.1.1.4

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Gallus gallus 5829
-
cytosol
-
 Rattus norvegicus 5829
-
cytosol
-
 Bos taurus 5829
-
cytosol
-
 Ovis aries 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
76000 78000
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetylserotonin + S-adenosyl-L-methionine Gallus gallus formation of the hormone melatonin S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
N-acetylserotonin + S-adenosyl-L-methionine Rattus norvegicus formation of the hormone melatonin S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
N-acetylserotonin + S-adenosyl-L-methionine Bos taurus formation of the hormone melatonin S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
N-acetylserotonin + S-adenosyl-L-methionine Ovis aries formation of the hormone melatonin S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Gallus gallus
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin reaction sequence is ordered bi-bi type Gallus gallus
a
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin reaction sequence is ordered bi-bi type Rattus norvegicus
a
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin reaction sequence is ordered bi-bi type Bos taurus
a
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin reaction sequence is ordered bi-bi type Ovis aries
a
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin addition of S-adenosyl-L-methionine occuring first followed by N-acetylserotonin Gallus gallus
a
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin addition of S-adenosyl-L-methionine occuring first followed by N-acetylserotonin Rattus norvegicus
a
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin addition of S-adenosyl-L-methionine occuring first followed by N-acetylserotonin Bos taurus
a
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin addition of S-adenosyl-L-methionine occuring first followed by N-acetylserotonin Ovis aries
a

Source Tissue

Source Tissue Comment Organism Textmining
pineal gland
-
 Gallus gallus
-
pineal gland
-
 Rattus norvegicus
-
pineal gland
-
 Bos taurus
-
pineal gland
-
 Ovis aries
-
retina
-
 Gallus gallus
-
retina
-
 Rattus norvegicus
-
retina
-
 Ovis aries
-

Storage Stability

Storage Stability Organism
4°C, 96 h, inactivated Rattus norvegicus
4°C, 96 h, pineal enzyme stable Bos taurus
4°C, 96 h, pineal enzyme stable Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetylserotonin + S-adenosyl-L-methionine formation of the hormone melatonin Gallus gallus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
N-acetylserotonin + S-adenosyl-L-methionine formation of the hormone melatonin Rattus norvegicus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
N-acetylserotonin + S-adenosyl-L-methionine formation of the hormone melatonin Bos taurus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
N-acetylserotonin + S-adenosyl-L-methionine formation of the hormone melatonin Ovis aries S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
S-adenosyl-L-methionine + N-acetylserotonin
-
 Gallus gallus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
S-adenosyl-L-methionine + N-acetylserotonin
-
 Rattus norvegicus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
S-adenosyl-L-methionine + N-acetylserotonin
-
 Bos taurus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
S-adenosyl-L-methionine + N-acetylserotonin
-
 Ovis aries S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?