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Literature summary for 2.1.1.376 extracted from

  • Ticak, T.; Kountz, D.J.; Girosky, K.E.; Krzycki, J.A.; Ferguson, D.J.
    A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase (2014), Proc. Natl. Acad. Sci. USA, 111, E4668-E4676 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.376

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Desulfitobacterium hafniense

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.96
-
 glycine betaine at pH 6.5 and 37°C Desulfitobacterium hafniense

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] Desulfitobacterium hafniense
-
 N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]
-
 ?
glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] Desulfitobacterium hafniense Y51
-
 N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Desulfitobacterium hafniense Q24SP7
-
-
Desulfitobacterium hafniense Y51 Q24SP7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein]
-
 Desulfitobacterium hafniense N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]
-
 ?
glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein]
-
 Desulfitobacterium hafniense Y51 N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]
-
 ?
glycine betaine + cob(I)alamin
-
 Desulfitobacterium hafniense N,N-dimethylglycine + methyl-cob(III)alamin
-
 ?
glycine betaine + cob(I)alamin
-
 Desulfitobacterium hafniense Y51 N,N-dimethylglycine + methyl-cob(III)alamin
-
 ?

Synonyms

Synonyms Comment Organism
DSY3156
-
 Desulfitobacterium hafniense
GB:corrinoid methyltransferase
-
 Desulfitobacterium hafniense
glycine betaine:corrinoid methyltransferase
-
 Desulfitobacterium hafniense
MtgB
-
 Desulfitobacterium hafniense