Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.371 extracted from

  • Chen, K.; Jian, D.; Zhao, L.; Zang, X.; Song, W.; Ma, J.; Jia, Z.; Wang, X.; Gao, C.
    Protective effect of histone methyltransferase NSD3 on ISO-induced cardiac hypertrophy (2019), FEBS Lett., 593, 2556-2565 .
    View publication on PubMed

Application

Application Comment Organism
medicine NSD3 expression is reduced by isoproterenol stimuli both in vitro and in vivo. Overexpression of NSD3 attenuates isoproterenol-induced cardiomyocyte hypertrophy. Isoproterenol treatment decreases H3K27me2/3 modifications on the atrial natriuretic factor promoter by suppressing NSD3 and inhibits the association between NSD3 and bromodomain-containing protein BRD4, thus suppressing the BRD4-mediated H3K27ac modifications, which ultimately promote atrial natriuretic factor transcription and cardiomyocyte hypertrophy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZ95
-
-

Expression

Organism Comment Expression
Homo sapiens NSD3 expression is reduced by isoproterenol stimuli both in vitro and in vivo down