Application | Comment | Organism |
---|---|---|
medicine | NSD3 expression is reduced by isoproterenol stimuli both in vitro and in vivo. Overexpression of NSD3 attenuates isoproterenol-induced cardiomyocyte hypertrophy. Isoproterenol treatment decreases H3K27me2/3 modifications on the atrial natriuretic factor promoter by suppressing NSD3 and inhibits the association between NSD3 and bromodomain-containing protein BRD4, thus suppressing the BRD4-mediated H3K27ac modifications, which ultimately promote atrial natriuretic factor transcription and cardiomyocyte hypertrophy | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BZ95 | - |
- |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | NSD3 expression is reduced by isoproterenol stimuli both in vitro and in vivo | down |