Literature summary for 2.1.1.370 extracted from

Shull, L.C.; Sen, R.; Menzel, J.; Goyama, S.; Kurokawa, M.; Artinger, K.B.
The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development (2020), Dev. Biol., 461, 132-144 .

Search for more literature for 2.1.1.370

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	A5XCD6	cf. EC 2.1.1.367	-

Synonyms

Synonyms	Comment	Organism
PRDM16	-	Danio rerio

General Information

General Information	Comment	Organism
physiological function	loss of Prdm3 or Prdm16 in zebrafish causes craniofacial defects including hypoplasia of the craniofacial cartilage elements, undefined posterior ceratobranchials, and decreased mineralization of the parasphenoid. Prdm3 and Prdm16 compensate for each other as well as a Prdm1a. Combinatorial loss of Prdm1a, Prdm3, and Prdm16 alleles results in severe hypoplasia of the anterior cartilage elements, abnormal formation of the jaw joint, complete loss of the posterior ceratobranchials, and clefting of the ethmoid plate. Loss of Prdm3 and Prdm16 reduces methylation of histone 3 lysine 9 (repression) and histone 3 lysine 4 (activation) in zebrafish	Danio rerio

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)