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Literature summary for 2.1.1.37 extracted from

  • Genenncher, B.; Durdevic, Z.; Hanna, K.; Zinkl, D.; Mobin, M.B.; Senturk, N.; Da Silva, B.; Legrand, C.; Carre, C.; Lyko, F.; Schaefer, M.
    Mutations in cytosine-5 tRNA methyltransferases impact mobile element expression and genome stability at specific DNA repeats (2018), Cell Rep., 22, 1861-1874 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + tRNAAspGUC
-
Drosophila melanogaster S-adenosyl-L-homocysteine + tRNAAspGUC containing 5-methylcytosine
-
?
S-adenosyl-L-methionine + tRNAGlyGCC
-
Drosophila melanogaster S-adenosyl-L-homocysteine + tRNAGlyGCC containing 5-methylcytosine
-
?
S-adenosyl-L-methionine + tRNAValAAC
-
Drosophila melanogaster S-adenosyl-L-homocysteine + tRNAValAAC containing 5-methylcytosine
-
?

Synonyms

Synonyms Comment Organism
Dnmt2
-
Drosophila melanogaster

General Information

General Information Comment Organism
physiological function mutations in two (cytosine-5) RNA methyltransferase Dnmt2 impact the accumulation of mobile element-derived sequences and DNA repeat integrity in Drosophila melanogaster. Loss of Dnmt2 function causes moderate effects under standard conditions, while heat shock exacerbates these effects. Dnmt2 mutants accumulate small RNA pathway substrate RNAs Drosophila melanogaster