Literature summary for 2.1.1.37 extracted from

Utsumi, S.; Sato, K.; Ichikawa, S.
Insight into the recognition mechanism of DNA cytosine-5 methyltransferases (DNMTs) by incorporation of acyclic 5-fluorocytosine (FC) nucleosides into DNA (2018), Bioorg. Med. Chem. Lett., 28, 2189-2194 .

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Application

Application	Comment	Organism
analysis	synthesis of acyclic nucleosides containing a 5-fluorouracil nucleobase, FC-ac1, and FC-ac2 to study the reaction mechanism. The oligodeoxynucleotides containing ODN-FC-ac1 and ODN-FC-ac2 show an increased flexiblilty. A negative correlation is observed between the flexibility and ODN-DNMT complex formation. A weaker nucleobase stacking effect due to the increase in flexibility at the acyclic modification site may provide a higher flip out effect, while the local flexibility would influence the scanning and recognition steps	Haemophilus parahaemolyticus

Organism

Organism	UniProt	Comment	Textmining
Haemophilus parahaemolyticus	P05102	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine	-	Haemophilus parahaemolyticus	a 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine	-	?
additional information	the entire reaction mechanism of DNMT is divided into six steps, which are scanning, recognition, flipping, loop locking, methylation, and releasing.	Haemophilus parahaemolyticus	?	-	-

Synonyms

Synonyms	Comment	Organism
hhaIM	-	Haemophilus parahaemolyticus
M.HhaI	-	Haemophilus parahaemolyticus

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Release 2023.1 (January 2023)